Abstract: As a key transportation infrastructure, the high-speed railway hub station is of great significance to ensure its seismic safety. Taking the structure of Changde high-speed railway hub station as the research object, the representative strong earthquake records are selected as the seismic bedrock motion. Considering the engineering geological characteristics of the site, soil nonlinearity, and pile-soil dynamic interaction, the finite element method is used to analyze the nonlinear earthquake response of the three-dimensional system of the high-speed railway station structure. The results show that: the structural system of a high-speed railway hub station considering pile-soil interaction presents the characteristics of 'soft-upper-rigid-down' as a whole, and the natural frequency is lower than that of the station structural system with rigid foundation assumption; Under the action of three kinds of strong ground motions, the nonlinear seismic effect of the site is significant, the surface acceleration is significantly enlarged, and the acceleration and displacement response of the site soil gradually decreases with the increase of buried depth; The interaction between pile and soil is related to the nonlinear seismic effect of the site. Both of them deform together to resist the foundation deformation caused by strong ground motion, and the strength of the interaction between the two increases with the increase of the intensity of ground shaking; Among the three kinds of seismic waves, the predominant frequency of Kobe wave is the closest to the natural frequency of the station structure system, followed by El Centro wave; The existence of the roof structure leads to the gradual amplification of the seismic response of the station frame structure with height, and the seismic response amplification at the connection between the roof structure and the base frame structure is the largest. Therefore, the maximum inter-story displacement Angle of the top layer of the station structure is greater than that of the bottom layer.